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The concept of "virus sovereignty" proposed by Indonesia in 2007 challenges the international tradition of virus sharing. In the context of the global outbreak of coronavirus disease 2019, the issue of virus sharing has become an important topic in the reform of the global health governance mechanisms. Virus sharing is an important guarantee of dealing with major global infectious diseases. However, the emergence of the concept of "virus sovereignty" shows that there are defects in the operation of virus sharing mechanism in the international community. The "virus sovereignty" problem is an ethical issue essentially, involving asymmetric interests hindering unity and cooperation, intellectual property rights expansion challenging the principle of solidarity, and excessive self-defense amplifying utility risks. "Community of common health for mankind" provides a constructive and feasible option to solve the dilemma of "virus sovereignty".
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In the development of chemo-immunotherapy, many efforts have been focusing on designing suitable carriers to realize the co-delivery of chemotherapeutic and immunotherapeutic with different physicochemical properties and mechanisms of action. Besides, rapid drug release at the tumor site with minimal drug degradation is also essential to facilitate the antitumor effect in a short time. Here, we reported a cancer cell membrane-coated pH-responsive nanogel (NG@M) to co-deliver chemotherapeutic paclitaxel (PTX) and immunotherapeutic agent interleukin-2 (IL-2) under mild conditions for combinational treatment of triple-negative breast cancer. In the designed nanogels, the synthetic copolymer PDEA-co-HP-β-cyclodextrin-co-Pluronic F127 and charge reversible polymer dimethylmaleic anhydride-modified polyethyleneimine endowed nanogels with excellent drug-loading capacity and rapid responsive drug-releasing behavior under acidic tumor microenvironment. Benefited from tumor homologous targeting capacity, NG@M exhibited 4.59-fold higher accumulation at the homologous tumor site than heterologous cancer cell membrane-coated NG. Rapidly released PTX and IL-2 enhanced the maturation of dendritic cells and quickly activated the antitumor immune response in situ, followed by prompted infiltration of immune effector cells. By the combined chemo-immunotherapy, enhanced antitumor effect and efficient pulmonary metastasis inhibition were achieved with a prolonged median survival rate (39 days).
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Objective:To investigate the effects of meditation therapy on fear of disease progress and mental health among acute myocardial infarction (AMI) patients.Methods:Totally, 120 cases of acute myocardial infarction patients admitted to Affiliated Hospital of Jiangnan University were divided into experimental group and control group according to the enrolled time. 60 patients with AMI treated from June to November 2018 served as the control group and 60 patients with AMI treated from January to May 2019 served as the experimental group. The patients in the control group received routine nursing, the experimental group carried out 4-week meditation therapy based on the routine nursing. Before and after intervention, the effect was assessed by Fear of Progression Questionnaire-Short Form (FoP-Q-SF) and Symptom Checklist-90 (SCL-90), respectively.Results:After intervention, the physical health and social family function dimension scores in FoP-Q-SF as well as total FoP-Q-SF scores were (12.78±3.47), (10.45±2.44), (23.24±4.25) points, significantly lower than in the control group (14.33±2.72), (11.59±2.82), (25.91±3.89) points, the difference was statistically significant ( t values were 2.623, 2.277, 3.499, P<0.05); the scores of somatization, compulsion, anxiety, depression and total SCL-90 were (1.26±0.19), (1.42±0.23), (1.19±0.28), (1.20±0.16) and (121.81±9.59) points, significantly lower than (1.83±0.25), (1.68±0.37), (1.82±0.41), (1.71±0.33) and (145.85±9.12) points in the control group, the difference was statistically significant ( t values were from 4.580 to 13.659, P<0.001). Conclusion:Meditation therapy can effectively decrease disease progress and promote mental health in patients with acute myocardial infarction.
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Acute respiratory distress syndrome (ARDS) is characterized by the severe inflammation and destruction of the lung air-blood barrier, leading to irreversible and substantial respiratory function damage. Patients with coronavirus disease 2019 (COVID-19) have been encountered with a high risk of ARDS, underscoring the urgency for exploiting effective therapy. However, proper medications for ARDS are still lacking due to poor pharmacokinetics, non-specific side effects, inability to surmount pulmonary barrier, and inadequate management of heterogeneity. The increased lung permeability in the pathological environment of ARDS may contribute to nanoparticle-mediated passive targeting delivery. Nanomedicine has demonstrated unique advantages in solving the dilemma of ARDS drug therapy, which can address the shortcomings and limitations of traditional anti-inflammatory or antioxidant drug treatment. Through passive, active, or physicochemical targeting, nanocarriers can interact with lung epithelium/endothelium and inflammatory cells to reverse abnormal changes and restore homeostasis of the pulmonary environment, thereby showing good therapeutic activity and reduced toxicity. This article reviews the latest applications of nanomedicine in pre-clinical ARDS therapy, highlights the strategies for targeted treatment of lung inflammation, presents the innovative drug delivery systems, and provides inspiration for strengthening the therapeutic effect of nanomedicine-based treatment.
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Objective:To describe a systematic approach on identification of poisonous mushroom by investigating two cases of Omphalotus guepiniformis poisoning in Jianyang district, Nanping, Fujian province. Methods:Two incidents of food poisoning on 10 migrant workers were investigated. The remaining suspected mushroom samples were collected and the same fresh mushroom specimens were also collected in the following field investigations from the same dead tree and fallen trunk. These mushroom specimens were identified based on morphological and phylogenetic analyses.Results:On November 24 and 26, 2018, 8 and 2 migrant workers from Jianyang District, Nanping ate wild mushrooms and developed acute nausea, vomiting, abdominal pain and other symptoms within 10 to 90 min after consumption. They were diagnosed as mushroom poisoning, with gastroenteritis as the main manifestation. Further analysis showed that the more poisonous mushroom were consumed, the shorter latency and longer duration of nausea and vomiting were resulted. After admission, gastric lavage, catharsis, acid preparation, gastric protection, fluid replenishment and other symptomatic support treatments were given in time, all patients were discharged in 1-3 d. Based on morphological and phylogenetic analyses, the samples were identified as O. guepiniformis. Conclusions:The two incidents were caused by accidental consumption of O. guepiniformis. Awareness education about poisonous mushroom should be provided to migrant workers to prevent more such poisoning incidents in the future.
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Blocking the programmed death-ligand 1 (PD-L1) on tumor cells with monoclonal antibody therapy has emerged as powerful weapon in cancer immunotherapy. However, only a minority of patients presented immune responses in clinical trials. To develop an alternative treatment method based on immune checkpoint blockade, we designed a novel and efficient CRISPR-Cas9 genome editing system delivered by cationic copolymer aPBAE to downregulate PD-L1 expression on tumor cells specifically knocking out Cyclin-dependent kinase 5 () gene . The expression of PD-L1 on tumor cells was significantly attenuated by knocking out , leading to effective tumor growth inhibition in murine melanoma and lung metastasis suppression in triple-negative breast cancer. Importantly, we demonstrated that aPBAE/Cas9-Cdk5 treatment elicited strong T cell-mediated immune responses in tumor microenvironment that the population of CD8 T cells was significantly increased while regulatory T cells (Tregs) was decreased. It may be the first case to exhibit direct PD-L1 downregulation CRISPR-Cas9 genome editing technology for cancer therapy. It will provide promising strategy for preclinical antitumor treatment through the combination of nanotechnology and genome engineering.
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Increasing sugar intake can be considered as a risk factor for some tumors, such as breast cancer, lung cancer, endometrial cancer, ovarian cancer, gallbladder cancer, pancreatic cancer, etc. Fructose can promote tumor formation and progression by several mechanisms, resulting in poor prognosis and increased chemotherapy resistance. Limitation of fructose consumption can reduce the risk of tumor, delay tumor progre-ssion and improve drug resistance, playing an auxiliary role in tumor treatment.
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Objective@#To explore the feasibility and clinical efficacy of serosal muscular layers incision and submucosal layers exfoliation technique in laparoscopic surgery for gastric gastrointestinal stromal tumors(GIST).@*Methods@#28 patients with gastric GIST underwent serosal muscular layers incision and submucosal layers exfoliation technique under laparoscopic surgery. Patients′clinicopathologic characteristics, operative outcomes, postoperative complications, and follow up results were analyzed retrospectively.@*Results@#Surgery was successfully completed in all patients, and no one was converted to open surgery.The average operation time was (66±15) min, and the intra operative blood loss was (16±10) ml, the time of passage of gas by anus after operation was (20±10)h, the time starting liquid diet was(2.5±1.6)d, and the length of postoperative hospital stay was (7±3)d. One patient had delayed gastric emptying, one had incisional infection. All the specimen had complete pseudocapsule and negative margin. pathology was all gastric GIST. After a median 22 months followed up, no recurrence or metastasis were found.@*Conclusion@#Serosal muscular layers incision and submucosal layers exfoliation under laparoscopic surgery is a safe and feasible procedure for treating gastric GIST.
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Objective To investigate the predictive value of CT signs in the pathological Fuhrman grading of clear cell renal carcinoma (ccRCC).Methods The clinicopathological features and CT findings of 72 patients with ccRCC which confirmed by operation and pathology were analyzed retrospectively.According to the WHO Fuhrman grading,all patients were divided into low-grade(Fuhrman gradeⅠorⅡ)or high-grade (Fuhrman gradeⅢorⅣ).ChiG square test and t-test were used to compare the clinical data and CT findings between the two groups,including morphological features (site,whether the renal medulla invasion,morphology,growth pattern,border,pseudo-envelope,lobulation sign,interface,perirenal fascia and the same lateral adrenal invasion,renal sinus and perirenal fat invasion,venous invasion,lymphadenopathy, maximum diameter),density (bleeding,necrosis ratio,calcification,fat)and enhancement characteristics (the degree of enhancement, strengthening method).And the pathological Fuhrman grading was the gold standard.The ROC was used to analyze the diagnostic efficacy of CT signs on Fuhrman grading.The Delong test was used to compare the AUC of different CT signs.Results There were significant differences in tumor maximum diameter,the renal medulla invasion,and lobulation sign between the Fuhrman low-grade and high-grade group(χ2/t＝－4.31 7,9.794,7.325,P＜0.05).There were no differences in gender,age,location sign,morphology,growth pattern, border,pseudo-envelope,interface,perirenal fascia and ipsilateral adrenal invasion,renal sinus and perirenal fat invasion,necrosis ratio,degree of enhancement,strengthening method between two groups (P＞0.05). The largest diameter of the tumor,the renal medulla invasion and the lobulation sign were useful for Fuhrman diagnosis.The AUC was 0.778,0.647 and 0.644,respectively.And there were significant differences between the maximum diameter and the renal medulla invasion or lobulation sign (P＜0.05).Conclusion The maximum diameter,medulla and lobular sign can predict the Fuhrman grading of ccRCC,and the maximum diameter prediction is the most accurate.
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Objective To explore the feasibility and clinical efficacy of serosal muscular layers incision and submucosal layers exfoliation technique in laparoscopic surgery for gastric gastrointestinal stromal tumors(GIST).Methods 28 patients with gastric GIST underwent serosal muscular layers incision and submucosal layers exfoliation technique under laparoscopic surgery.Patients' clinicopathologic characteristics,operative outcomes,postoperative complications,and follow up results were analyzed retrospectively.Results Surgery was successfully completed in all patients,and no one was converted to open surgery.The average operation time was (66 ± 15) min,and the intra operative blood loss was (16 ± 10) ml,the time of passage of gas by anus after operation was (20 ± 10)h,the time starting liquid diet was (2.5 ± 1.6) d,and the length of postoperative hospital stay was (7 ± 3) d.One patient had delayed gastric emptying,one had incisional infection.All the specimen had complete pseudocapsule and negative margin.pathology was all gastric GIST.After a median 22 months followed up,no recurrence or metastasis were found.Conclusion Serosal muscular layers incision and submucosal layers exfoliation under laparoscopic surgery is a safe and feasible procedure for treating gastric GIST.
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Drug delivery systems (DDS) are defined as methods by which drugs are delivered to desired tissues, organs, cells and subcellular organs for drug release and absorption through a variety of drug carriers. Its usual purpose to improve the pharmacological activities of therapeutic drugs and to overcome problems such as limited solubility, drug aggregation, low bioavailability, poor biodistribution, lack of selectivity, or to reduce the side effects of therapeutic drugs. During 2015-2018, significant progress in the research on drug delivery systems has been achieved along with advances in related fields, such as pharmaceutical sciences, material sciences and biomedical sciences. This review provides a concise overview of current progress in this research area through its focus on the delivery strategies, construction techniques and specific examples. It is a valuable reference for pharmaceutical scientists who want to learn more about the design of drug delivery systems.
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To explore the clinical characters, treatment and prognosis for pediatric optic pathway gliomas (OPGs). Methods: A total of 26 patients with OPGs, who were diagnosed and treated at Neurosurgery of Xiangya Hospital of Central South University between June 2010 and November 2017, were retrospectively reviewed, and their average age was 5.5 years old. The influential factors for patients' progression-free survival (PFS) and overall survival (OS) were analyzed. Results: All patients were classified into Type II and Type III based on Dodge classification and received surgery treatment. Vision was improved after surgery in 20 patients. Twenty-four patients (92.3%) were continually followed up, and 14 patients (58.3%) received post-radiation treatment. Twenty-one patients were still alive and 15 patients' symptoms were not progressed. The PFS and OS in patients received radiation therapy were better than those without radiation therapy (PFS: P<0.01; OS: P<0.05). The postoperative visual prognosis might be related to the choice of surgical approach. Conclusion: Treatment of children with OPGs should include surgery and postoperative radiotherapy. The eyesight protection in surgery is as important as tumor resection.
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Child, Preschool , Humans , Disease-Free Survival , Glioma , Neurosurgical Procedures , Prognosis , Retrospective StudiesABSTRACT
Increasing sugar intake can be considered as a risk factor for some tumors,such as breast cancer,lung cancer,endometrial cancer,ovarian cancer,gallbladder cancer,pancreatic cancer,etc.Fructose can promote tumor formation and progression by several mechanisms,resulting in poor prognosis and increased chemotherapy resistance.Limitation of fructose consumption can reduce the risk of tumor,delay tumor progression and improve drug resistance,playing an auxiliary role in tumor treatment.
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Objective To evaluate circulating tumor cells (CTC) in prognosis prediction of gastric cancer.Method Peripheral blood samples were obtained from 65 patients with gastric cancer and 20 normal volunteers.CTC were detected by using CellSearch(R) CTC Detecting System.Postoperative progress-free survival (PFIS) and overall survival (OS) were evaluated against CTC status and clinicopathological factors.Result CTC were positive in 35 out of 65 (53％) patients compared to 1 out of 20 (5％) healthy controls,P ＜ 0.05.CTC were not statistically corelated with patients' age,sex and lymph node status or distal metastasis,vascular invasion and tumor markers (all P ＞ 0.05).CTC positive patients had poorer OS (P ＜ 0.05) and PFS (P ＜ 0.05) compared with those with negative CTC.Conclusion Positive CTC in gastric cancer patients predict poor prognosis after radical gastrectomy.
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Objective To investigate the application value of secondary splenic pedicle separation technology through superior posterior approach of the pancreatic tail in laparoscopic partial splenectomy.Methods The retrospective cross-sectional study was conducted.The clinicopathological data of 13 patients who underwent laparoscopic partial splenectomy in the Ningbo First Hospital from March 2016 to October 2017 were collected.After preoperative assessment using computed tomography(CT) angiography,13 patients underwent laparoscopic partial splenectomy using secondary splenic pedicle separation technology through superior posterior approach of the pancrcatic tail.Observation indicators:(1) intra-and post-operative recovery situations;(2) follow-up situations.Follow-up using outpatient examination was performed to detect postoperative changes of peripheral blood platelet (PLT),thrombosis of splenic vein,lesions residual or recurrence up to November 2017.Measurement data were represented as average (range).Results (1) Intra-and post-operative recovery situations:13 patients underwent successful laparoscopic partial splenectomy using secondary splenic pedicle separation technology through superior posterior approach of the pancreatic tail,without conversion to open surgery,including 6 with laparoscopic partial splenectomy of inferior pole of the spleen and 7 with laparoscopic partial splenectomy of upper pole of the spleen.Operation time was 42-93 minutes,with an average of 61 minutes;volume of intraoperative blood loss was 30-260 mL,with an average of 92 mL;postoperative gastrointestinal function recovery time was 22-47 hours,with an average of 34 hours;postoperative drainage tube removal time was 3.0-6.0 days,with an average of 4.2 days.The postoperative pathological examination of 13 patients:7,2,2,1 and 1 patients were respectively confirmed with splenic cysts,splenic hemangiomas,vascular hemangiomas,splenic hamartoma and splenic lymphangioma.Of 13 patients,1 was complicated with splenic recess effusion and fever,and was improved with B ultrasound-guided percutaneous catheter drainage.Duration of hospital stay of 13 patients was 7.0-16.0 days,with an average of 9.6 days.(2) Follow-up situations:13 patients were followed up for 1.0-19.5 months,with a median time of 8.5 months.During the follow-up,PLT level of 13 patients was normal.Color Doppler ultrasound examination showed no venous embolism,and CT angiography showed good vascular perfusion.There was no recurrence of splenic cysts in 7 patients and no tumor residual or recurrence in 6 patients.Conclusion Laparoscopic partial splenectomy using secondary splenic pedicle separation technology through superior posterior approach of the pancreatic tail is safe and effective,and it can precisely dissect splenic hilum,preserve blood supply and function of the remnant spleen,and reduce surgical injury.
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Objective To investigate the risks of pre-pregnancy overweight,excessive gestational weight gain on macrosomia.Methods We conducted one hospital-based cohort study,focusing on pregnant women from January 2015.All pregnant women attending to this hospital for maternal check-ups,were included in our cohort and followed to the time of delivery.Data related to general demographic characteristics,pregnancy and health status of those pregnant women,was collected and maternal pre-pregnant BMI and maternal weight gain were calculated.Logistic regression was used to explore the risk difference of pre-pregnancy BMI,excessive gestational weight gain on macrosomia.Results The overall incidence of macrosomia in our cohort appeared as 6.6％ (149/2 243).After adjusting the confounding factors including age and histories on pregnancy,prepregnancy overweight/obesity was associated with higher risks of macrosomia (OR=3.12,95％ CI:1.35-7.22,P=0.008;OR=2.99,95％CI:1.17-7.63,P=0.022) when comparing to those with normal pre-pregnancy weight.Cesarean delivery and sex of the offspring were associated with higher risk of macrosomia,while excessive gestational weight gain showed no significant difference (OR=1.41,95％CI:0.96-2.09,P=0.084).Our data showed that Macrosomia was statistically associated with gestational weight gain (P=0.002).After controlling parameters as age,history of pregnancy and related complications of the pregnant women,results from the logistic regression showed that women with gestational inadequate weight gain having reduced risks to deliver macrosomia,when compared to those pregnant women with adequate weight gain (OR=0.52,95％ CI:0.30-0.90,P=0.019).Conclusion Pre-pregnancy overweight and obesity were on higher risks to macrosomia.
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Objective To investigate the risks of pre-pregnancy overweight,excessive gestational weight gain on macrosomia.Methods We conducted one hospital-based cohort study,focusing on pregnant women from January 2015.All pregnant women attending to this hospital for maternal check-ups,were included in our cohort and followed to the time of delivery.Data related to general demographic characteristics,pregnancy and health status of those pregnant women,was collected and maternal pre-pregnant BMI and maternal weight gain were calculated.Logistic regression was used to explore the risk difference of pre-pregnancy BMI,excessive gestational weight gain on macrosomia.Results The overall incidence of macrosomia in our cohort appeared as 6.6％ (149/2 243).After adjusting the confounding factors including age and histories on pregnancy,prepregnancy overweight/obesity was associated with higher risks of macrosomia (OR=3.12,95％ CI:1.35-7.22,P=0.008;OR=2.99,95％CI:1.17-7.63,P=0.022) when comparing to those with normal pre-pregnancy weight.Cesarean delivery and sex of the offspring were associated with higher risk of macrosomia,while excessive gestational weight gain showed no significant difference (OR=1.41,95％CI:0.96-2.09,P=0.084).Our data showed that Macrosomia was statistically associated with gestational weight gain (P=0.002).After controlling parameters as age,history of pregnancy and related complications of the pregnant women,results from the logistic regression showed that women with gestational inadequate weight gain having reduced risks to deliver macrosomia,when compared to those pregnant women with adequate weight gain (OR=0.52,95％ CI:0.30-0.90,P=0.019).Conclusion Pre-pregnancy overweight and obesity were on higher risks to macrosomia.
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OBJECTIVE:To optimize the methanol extraction technology of tripterine in the fruit of Celastrus monospermus. METHODS:HPLC was adopted to determine the content of tripterine. Using extraction time,extraction times,solid-liquid ratio as investigation factors,extraction rate of tripterine as investigation index,orthogonal test was designed,and verification test was con-ducted. RESULTS:The optimal methanol extraction technology was as follow as 45% methanol extracting 2 h each time with sol-id-liquid ratio of 1:8 for 3 times. In the verification test,the average extraction rate of tripterine was 0.917 mg/g(RSD=2.85%, n=3). CONCLUSIONS:The optimized methanol extraction technology is stable and feasible with high extraction rate,and is suit-able for the extraction of tripterine in the fruit of C. monospermus.
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Objective To know the focus groups' iodine nutrition level after implementation of a new standard of salt iodization,and to provide technical support for iodine deficiency disorders (IDD) prevention in Nanping City.Methods According to the requirements of Focus Groups' Iodine Nutrition and Related Health Monitoring Program in Fujian Province,Yanping,Jian'ou,Zhenghe,Jianyang and Shaowu counties (cities,districts) were selected for monitoring in 2014;Pucheng,Songxi,Wuyishan,Shunchang and Guangze counties (cities,districts) were selected for monitoring in 2015.We studied:①The water iodine:2 tap water samples were collected from centralized water supply system;from decentralized water supply system,2 residents drinking water samples were collected according to each of five directions of east,west,south,north,and center,for determination of water iodine content.②Salt iodine:4 administrative villages (neighborhood committees) were selected from each monitoring site,from which 15 households were selected,edible salt samples were collected,and salt iodine content was tested.③Urinary iodine:one primary school was selected from each monitoring site,30-40 students aged from 8-10 years old were selected from each primary school,urine samples were collected for detecting urinary iodine.④Salt intake per capita:among the 8-10 years old students whom had been collected urine samples,10 students' family edible salt samples were collected,then the salt intake per capita was measured via 3-days weighing method.⑤ Goiter:in Jianyang and Shaowu Cities in 2014,and in Guangze and Shunchang Cities in 2015,the thyroid volume was measured using ultrasound,and goiter rate was calculated of 8-10 years old students whom had been collected urine samples before.⑥Pregnant women urinary iodine:20 pregnant women (early,middle and late pregnancy were included) were selected in each monitoring site,urine samples were collected for detecting urinary iodine.Results Investigation results in 2014 and 2015 were as follows:61 and 50 samples of daily drinking water of the two years were investigated,the medians of drinking water iodine were 1.5 and 5.7 μg/L for each group of samples,respectively;and daily salt intake of 253 and 250 residents of the two years were investigated,and the medians intake were 6.8 and 6.9 g/d,respectively;1 500 and 1 500 residential edible salt samples in the two years were tested,iodized salt coverage rates were 99.7％ (1 496/1 500) and 99.9％ (1 498/1 500),respectively,qualified rates of iodized salt were 95.7％ (1 431/1 496) and 94.5％ (1 416/1 498),respectively,qualified iodized salt consumption rates were 95.4％ (1 431/1 500) and 94.4％ (1 416/ 1 500),respectively;of which 749 and 1 000 8-10 years old children's urinary iodine were also tested,and children's urinary iodine medians were 190.1 and 210.4 μg/L,respectively;300 and 275 thyroids of children aged from 8 to 10 were tested,and goiter rates (ultrasound method) were 1.3％ (4/300) and 2.9％ (8/275),respectively;500 and 500 pregnant women urinary iodine were tested in the two years,and pregnant women urinary iodine medians were 133.2 and 150.3 μg/L,respectively,the pregnant women urinary iodine median of the Nanping City of 10 counties (cities,districts) and 7 counties (cities,districts) were less than 150 μg/L.Conclusions Nanping City's natural environment iodine is deficient.After the new standard of salt iodization,we can continue to promote the process of the standard of eliminating IDD in China,besides,8-10 years old children's iodine nutrition is basically at the appropriate level,but the level of pregnant women has showed a slightly deficiency.
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Objective To observe the clinical value of application of low-dose scanning technology in dual source CT coronary angiography.Methods 200 cases who received coronary artery imaging were randomly selected as the study subjects.Patients were divided into the observation group and the control group using the random number method,100 cases in each group.All patients underwent dual source CT angiography.The observation group was treated by adaptive prospective ECG gated sequence,the control group was treated with retrospective ECG gated sequences.The image quality and radiation dose to bear were compared between the two groups.Results The various stages of image score proportion between the two groups had no significant difference(P＞0.05).The average score of reading image of the observation group was (1.52±0.33)points,which of the control group was (1.48±0.46)points,there was no difference between the two groups(t=0.857,P＞0.05).The CTDL,DLP and ED in the observation group were significantly lower than the control group[the observation group:CTDL(23.41±5.82),DLP(224.61±85.44),ED(3.01±1.12)mSv;the control group:CTDL(34.09±6.77),DLP(82.93±94.28),ED(5.33±2.01)mSv],and the differences were statistically significant(t=11.963,12.443,10.083,all P＜0.05)].Conclusion Prospective ECG gated sequence technology can effectively reduce the radiation dose of the patients under dual source CT coronary angiography,reduce probability of radiation damage,and the image quality is not changed obviously,which meets the needs of clinical diagnosis.